Objective:This study is aimed to evaluate the safety, feasibility, and efficacy of a novel technique: laparoscopic sleeve gastrectomy with loop gastroileal bypass.Summary of Background Data:Standard bariatric surgeries, such as sleeve gastrectomy and Roux-en-Y gastric bypass, although very effective, carry certain inherent limitations and inevitable sequelae. Newer bariatric/metabolic surgeries are required to address these limitations.Methods:Between February 2016 and February 2018, a total of 113 Indians suffering from obesity with or without type 2 diabetes underwent sleeve gastrectomy with loop gastroileal bypass. Meticulous analysis of prospectively documented data was performed.Results:Mean age was 40.74 ± 10.4 years, mean body mass index was 43.48 ± 7.57 kg/m2. A total of 54 of 113 patients (47.79%) had type 2 diabetes. Mean duration of surgery was 148.36 ± 38.56 minutes. Common channel length was 250 cm in 18 patients, 300 cm in 88 patients, and 350 cm in 7 patients. There were no major complications, such as major intra-abdominal bleeding, perforation, or leak. According to Indian standards, when 23 kg/m2 was taken as a cutoff upper limit for normal weight, percentage of excess weight loss was 25.04% ± 10.13%, 67.81% ± 23.17% and 94.33% ± 24.96%, respectively, at 1, 6, and 12 months after surgery. A total of 51 of 54 patients with type 2 diabetes stopped using antidiabetes medications within 1 week after surgery.Conclusion:Laparoscopic sleeve gastrectomy with loop gastroileal bypass appears to be a promising procedure to address limitations associated with standard bariatric procedures.