Current legal regulations concerning ozone-depleting substances and greenhouse gases result in a dynamic return to the use of natural refrigerants such as hydrocarbons. However, they are gases included in the A3 (combustible) security group, and that is why they are now mainly used in devices with low performance (mainly in household refrigerators). The most widely used hydrocarbon as a refrigerant in this group of devices is R600a (isobutene). The article presents a comparative assessment of the lubricity properties of oil-refrigerant mixtures of three mineral oils with R600a. The assessment was based on a sample wear volume of the block-on-ring node under the conditions approximating the operation of the compressor after an extensive standstill period. The oil/refrigerant mixture was obtained as a result of an appropriately extended mutual contact of both substances in a closed chamber.