AbstractObjectiveTo evaluate whether the results of a quasi‐randomized study, comparing dialectical behavior therapy for binge‐eating disorder (DBT‐BED) and an intensive, outpatient cognitive behavior therapy (CBT+) in individuals with BED, would be replicated in a nonrandomized study with patients who more closely resemble everyday clinical practice.MethodPatients with (subthreshold) BED (N = 175) started one of two group treatments: DBT‐BED (n = 42) or CBT+ (n = 133), at a community eating disorder service. Measures of eating disorder pathology, emotion regulation, and general psychopathology were examined at end of treatment (EOT) and at 6‐month follow‐up using generalized linear models with multiple imputation.ResultsBoth treatments lead to substantial decreases on primary and secondary measures. Statistically significant, medium‐size differences between groups were limited to global eating disorder psychopathology (d = −.62; 95% CI = .231, .949) at EOT and depressive symptoms at follow‐up (d = −.45; 95% CI = .149, 6.965), favoring CBT+. Dropout of treatment included 15.0% from CBT+ and 19.0% from DBT‐BED (difference nonsignificant).DiscussionDecreases in global eating disorder psychopathology were achieved faster with CBT+. Overall, improvements in DBT‐BED were comparable to those observed in CBT+. Findings of the original trial, favoring CBT+ on the number of OBE episodes, emotional dysregulation and self‐esteem at EOT, and on eating disorder psychopathology and self‐esteem at follow‐up, were not replicated. With similar rates of treatment dropout and about half of the therapy time used in CBT+, DBT‐BED can be considered a relevant treatment for BED in everyday clinical practice.Public SignificanceIn this effectiveness study, dialectical behavior therapy (DBT) resulted in clinically relevant improvements in individuals with binge eating disorder. Changes were broadly comparable to those of cognitive behavior therapy (CBT), the current treatment of choice. Although CBT resulted in decreases in eating disorder psychopathology faster, there was a trend toward relapse in CBT at 6‐month follow‐up. Therefore, the less costly DBT‐program can be considered a relevant treatment in clinical practice.