Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group
Copyright policy )Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group
To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3'-TYMS -6bp/-6bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway.
- Universiti Malaysia Terengganu Malaysia
- National University of Singapore Singapore
- University of Malaya Malaysia
- University Health System United States
- National University Health System Singapore
Male, Adolescent, Genotype, 610, R Medicine, Polymorphism, Single Nucleotide, Childhood ALL, Young Adult, Gender effect, Asian People, Humans, Genetic epidemiology, Genetic Predisposition to Disease, Polymorphism, Child, Malay, Sex Characteristics, Singapore, Infant, Newborn, Malaysia, Infant, Folate metabolism, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Child, Preschool, NQO1, Female
Male, Adolescent, Genotype, 610, R Medicine, Polymorphism, Single Nucleotide, Childhood ALL, Young Adult, Gender effect, Asian People, Humans, Genetic epidemiology, Genetic Predisposition to Disease, Polymorphism, Child, Malay, Sex Characteristics, Singapore, Infant, Newborn, Malaysia, Infant, Folate metabolism, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Child, Preschool, NQO1, Female
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).50 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!