Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia
Copyright policy )Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia
AbstractThis article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid‐β1–42, tau, and phosphorylated tau in the diagnostic evaluation of patients with dementia. The recommendations were developed by a multidisciplinary working group based on the available evidence and consensus from focused discussions for (i) identification of Alzheimer's disease (AD) as the cause of dementia, (ii) prediction of rate of decline, (iii) cost‐effectiveness, and (iv) interpretation of results. The working group found sufficient evidence to support a recommendation to use CSF AD biomarkers as a supplement to clinical evaluation, particularly in uncertain and atypical cases, to identify or exclude AD as the cause of dementia. Because of insufficient evidence, it was uncertain whether CSF AD biomarkers outperform imaging biomarkers. Operational recommendations for the interpretation of ambiguous CSF biomarker results were also provided.
- Polish Academy of Learning Poland
- Maastricht University Netherlands
- Turku University Hospital Finland
- University of Geneva Switzerland
- University of Gothenburg Sweden
MILD COGNITIVE IMPAIRMENT, Alzheimer disease - cerebrospinal fluid, Epidemiology, Review, Recommendations, GUIDELINES, Alzheiiner's disease, Alzheimer Disease/cerebrospinal fluid, COST-EFFECTIVENESS, Bibliographic/statistics & numerical data, Databases, Bibliographic/statistics & numerical data, ALZHEIMERS-DISEASE DIAGNOSIS, PHOSPHORYLATED TAU, Diagnosis, GRADING QUALITY, CRITERIA, Health Policy, Alzheimer's disease, Psychiatry and Mental health, GRADE, Peptide fragments - cerebrospinal fluid, Biomarkers - cerebrospinal fluid, Peptide Fragments/cerebrospinal fluid, Clinical Neurology, CSF, tau Proteins, ta3112, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016454, Databases, Cellular and Molecular Neuroscience, Developmental Neuroscience, Alzheimer Disease, Journal Article, MANAGEMENT, Humans, Biomarkers/cerebrospinal fluid, bibliographic - statistics & numerical data, METAANALYSIS, Amyloid beta-Peptides, tau Proteins/cerebrospinal fluid, Alzheimer's disease; Biomarkers; CSF; Diagnosis; GRADE; Recommendations, Databases, Bibliographic, Amyloid beta-Peptides/cerebrospinal fluid, ta3124, Peptide Fragments, Tau proteins - cerebrospinal fluid, Amyloid beta-peptides - cerebrospinal fluid, 616.89, Alzheimer disease - diagnosis, Human medicine, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Geriatrics and Gerontology, Biomarkers, CEREBROSPINAL-FLUID TAU, ddc: ddc:616.89
MILD COGNITIVE IMPAIRMENT, Alzheimer disease - cerebrospinal fluid, Epidemiology, Review, Recommendations, GUIDELINES, Alzheiiner's disease, Alzheimer Disease/cerebrospinal fluid, COST-EFFECTIVENESS, Bibliographic/statistics & numerical data, Databases, Bibliographic/statistics & numerical data, ALZHEIMERS-DISEASE DIAGNOSIS, PHOSPHORYLATED TAU, Diagnosis, GRADING QUALITY, CRITERIA, Health Policy, Alzheimer's disease, Psychiatry and Mental health, GRADE, Peptide fragments - cerebrospinal fluid, Biomarkers - cerebrospinal fluid, Peptide Fragments/cerebrospinal fluid, Clinical Neurology, CSF, tau Proteins, ta3112, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016454, Databases, Cellular and Molecular Neuroscience, Developmental Neuroscience, Alzheimer Disease, Journal Article, MANAGEMENT, Humans, Biomarkers/cerebrospinal fluid, bibliographic - statistics & numerical data, METAANALYSIS, Amyloid beta-Peptides, tau Proteins/cerebrospinal fluid, Alzheimer's disease; Biomarkers; CSF; Diagnosis; GRADE; Recommendations, Databases, Bibliographic, Amyloid beta-Peptides/cerebrospinal fluid, ta3124, Peptide Fragments, Tau proteins - cerebrospinal fluid, Amyloid beta-peptides - cerebrospinal fluid, 616.89, Alzheimer disease - diagnosis, Human medicine, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Geriatrics and Gerontology, Biomarkers, CEREBROSPINAL-FLUID TAU, ddc: ddc:616.89
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