Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
Copyright policy )Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
Thousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain (MYH) genes and linc-MYH share a common enhancer, located in the fast MYH gene locus and regulated by Six1 homeoproteins. linc-MYH in nuclei of fast-type myofibers prevents slow-type and enhances fast-type gene expression. Functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast MYHs and linc-MYH, under the control of a common Six-bound enhancer.
- Sorbonne University France
- Inserm France
- UNIVERSITE PARIS DESCARTES France
- University of Paris France
- PSL Research University France
Homeodomain Proteins, Mice, Knockout, Extracellular Matrix Proteins, Myosin Heavy Chains, Gene Expression Regulation, Developmental, [SDV.GEN] Life Sciences [q-bio]/Genetics, QH426-470, Protein-Lysine 6-Oxidase, Enhancer Elements, Genetic, Genetics, Animals, RNA, Long Noncoding, Cloning, Molecular, Muscle, Skeletal, Research Article, Muscle Contraction
Homeodomain Proteins, Mice, Knockout, Extracellular Matrix Proteins, Myosin Heavy Chains, Gene Expression Regulation, Developmental, [SDV.GEN] Life Sciences [q-bio]/Genetics, QH426-470, Protein-Lysine 6-Oxidase, Enhancer Elements, Genetic, Genetics, Animals, RNA, Long Noncoding, Cloning, Molecular, Muscle, Skeletal, Research Article, Muscle Contraction
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