Two new species of the caridean shrimp genus Hippolyte Leach, 1814 [in Leach, 1813-14] are described from the Tropical Central and East Atlantic. Hippolyte cedrici sp. nov., from Príncipe and São Tomé, can be distinguished from both the related H. holthuisi Zariquey Álvarez, 1953 and H. varians Leach, 1814 on the basis of rostral dentition, as well as meristics of the ambulatory pereiopods. Hippolyte karenae sp. nov., from St. Helena, is morphologically similar to H. coerulescens (Fabricius, 1775) and H. obliquimanus Dana, 1852, by having a well-developed tooth on the outer angle of the first peduncular article of the antennula. It differs from these species, amongst other characters, primarily in the armature of the ambulatory dactyli. Specimens were collected from hydrozoan, antipatharian and alcyonarian cnidarians.