A trial was conducted to determine the effect of replacing conventional soybean meal (CSBM) with low-oligosaccharide soybean meal (LOSBM) on growth performance and carcass characteristics of wean-to-finish pigs. A total of 432 crossbred pigs (19 d and 6.6 ± 1.2 kg BW) were blocked by sex and BW and assigned to 1 of 6 dietary treatments: 1) CSBM in all phases and fishmeal and spray-dried plasma protein (FM/SDPP) in phases 1 to 3, 2) CSBM in all phases but with no FM/SDPP, 3) LOSBM and FM/SDPP in phases 1 to 3 and CSBM in phases 4 to 6, 4) LOSBM in phases 1 to 3 and CSBM in phases 4 to 6, 5) LOSBM in phases 1 to 6 and FM/SDPP in phases 1 to 3, and 6) LOSBM in phases 1 to 6. The results showed that pig growth performance (ADG, ADFI, and G:F) during the overall period (phases 1 to 6) and carcass traits (HCW, dressing percentage, fat depth, loin depth, and lean percentage) were not affected ( > 0.05) by dietary treatments. Moreover, replacing CSBM with LOSBM in phases 1 to 3 did not affect early phase growth performance in the absence of FM/SDPP but reduced ( ≤ 0.05) ADFI and increased ( < 0.05) G:F during the nursery period (phases 1 and 2) in the presence of FM/SDPP. In phase 2, LOSBM increased ( < 0.05) blood urea nitrogen in comparison with CSBM. In conclusion, reduction of oligosaccharide by replacing CSBM with LOSBM in the early, late, or entire phase of the wean-to-finish period did not improve growth performance and carcass characteristics of pigs.