Role of stress system disturbance and enhanced novelty response in spatial learning of NCAM-deficient mice
Copyright policy )Role of stress system disturbance and enhanced novelty response in spatial learning of NCAM-deficient mice
The neural cell adhesion molecule (NCAM) plays a crucial role in stress-related brain function, emotional behavior and memory formation. In this study, we investigated the functions of the glucocorticoid and serotonergic systems in mice constitutively deficient for NCAM (NCAM-/- mice). Our data provide evidence for a hyperfunction of the hypothalamic-pituitary-adrenal axis, with enlarged adrenal glands and increased stress-induced corticosterone release, but reduced hippocampal glucocorticoid receptor expression in NCAM-/- mice when compared to NCAM+/+ mice. We also obtained evidence for a hypofunction of 5-HT1A autoreceptors as indicated by increased 8-0H-DPAT-induced hypothermia. These findings suggest a disturbance of both humoral and neural stress systems in NCAM-/- mice. Accordingly, we not only confirmed previously observed hyperarousal of NCAM-/- mice in various anxiety tests, but also observed an increased response to novelty exposure in these animals. Spatial learning deficits of the NCAM-/- mice in a Morris Water maze persisted, even when mice were pretrained to prevent effects of novelty or stress. We suggest that NCAM-mediated processes are involved in both novelty/stress-related emotional behavior and in cognitive function during spatial learning.
- Rutgers, The State University of New Jersey United States
- Universität Hamburg Germany
- Otto-von-Guericke University Magdeburg Germany
- University of New Brunswick Canada
- Shantou University Medical College China (People's Republic of)
8-Hydroxy-2-(di-n-propylamino)tetralin, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Hypothermia, Anxiety, Motor Activity, Hippocampus, Mice, Memory, Short-Term, Receptors, Glucocorticoid, Animals, Corticosterone, Maze Learning, Neural Cell Adhesion Molecules, Stress, Psychological
8-Hydroxy-2-(di-n-propylamino)tetralin, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Hypothermia, Anxiety, Motor Activity, Hippocampus, Mice, Memory, Short-Term, Receptors, Glucocorticoid, Animals, Corticosterone, Maze Learning, Neural Cell Adhesion Molecules, Stress, Psychological
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