DRL1, a Homolog of the Yeast TOT4/KTI12 Protein, Has a Function in Meristem Activity and Organ Growth in Plants
Copyright policy )DRL1, a Homolog of the Yeast TOT4/KTI12 Protein, Has a Function in Meristem Activity and Organ Growth in Plants
The DEFORMED ROOTS AND LEAVES1 (DRL1) gene is single copy in the Arabidopsis genome, and based on overall amino acid similarity and conservation of functional domains, the DRL1 protein is homologous with yeast TOT4/KTI12. TOT4/KTI12 associates with Elongator, a multisubunit complex that binds the RNA polymerase II transcription elongation complex. Recessive mutations at the DRL1 locus caused defective organ formation indicative of disorganized shoot, inflorescence, flower, and root meristems. DRL1 is a putative ATP/GTP binding protein; in addition, calmodulin binding activity was demonstrated in vitro for the C terminus of the DRL1 protein. Phenotypic and genetic data position DRL1 relative to regulatory loci for leaf development, in which it acts early. We identified Arabidopsis homologs for the six Elongator components and hypothesize that DRL1 regulates transcription elongation through a putative plant Elongator. Upregulation of the ANGUSTIFOLIA transcript in the strong drl1-2 allele supports this model.
- Bayer (Belgium) Belgium
- John Innes Centre United Kingdom
- University of Illinois at Urbana–Champaign United States
- Ghent University Belgium
- Bayer Germany
Saccharomyces cerevisiae Proteins, Arabidopsis Proteins, Meristem, Molecular Sequence Data, Arabidopsis, Gene Expression Regulation, Developmental, DNA-Binding Proteins, Plant Leaves, Repressor Proteins, Phenotype, Calmodulin, GTP-Binding Proteins, Gene Expression Regulation, Plant, Mutation, Calcium, Amino Acid Sequence, Adaptor Proteins, Signal Transducing
Saccharomyces cerevisiae Proteins, Arabidopsis Proteins, Meristem, Molecular Sequence Data, Arabidopsis, Gene Expression Regulation, Developmental, DNA-Binding Proteins, Plant Leaves, Repressor Proteins, Phenotype, Calmodulin, GTP-Binding Proteins, Gene Expression Regulation, Plant, Mutation, Calcium, Amino Acid Sequence, Adaptor Proteins, Signal Transducing
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