Dysfibrinogenemia (Fibrinogen Dusard) Associated with Impaired Fibrin-Enhanced Plasminogen Activation

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1984 English Publisher:Georg Thieme Verlag KGJournal:Thrombosis and Haemostasis, volume 51, pages 108-109 (issn: 0340-6245, eissn: 2567-689X,

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Authors: H R, Lijnen; J, Soria; C, Soria; D, Collen; J P, Caen;

doi: 10.1055/s-0038-1661033

pmid: 6539000

Dysfibrinogenemia (Fibrinogen Dusard) Associated with Impaired Fibrin-Enhanced Plasminogen Activation

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Abstract

SummaryThe fibrin-mediated enhancement of the activation of plasminogen by tissue-type plasminogen activator observed with normal fibrin, is strongly decreased with fibrin Dusard, although the binding of tissue-type plasminogen activator to this fibrin is normal. This impaired fibrin-mediated plasminogen activation is most likely related to the history of recurrent thrombosis and pulmonary embolism observed in this family.

Related Organizations

KU Leuven
Belgium
French Institute of Health and Medical Research
France
Katholieke Universiteit Leuven
Belgium
Assistance Publique -Hopitaux De Paris
France
Lariboisière Hospital
France

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Keywords

Fibrin, Plasminogen Activators, Fibrinogens, Abnormal, Fibrinolysis, Fibrinogen, Humans, Plasminogen, Blood Coagulation Disorders

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