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The analysis of association between type 2 diabetes and polymorphic markers in the CDKAL1 gene and in the HHEX/IDE locus

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2016 English Publisher:Pleiades Publishing LtdJournal:Russian Journal of Genetics, volume 52, pages 1,192-1,199 (issn: 1022-7954, eissn: 1608-3369,

Authors: Brovkin An; M. Yu. Mayorov; E. Yu. Lavrikova; V. A. Potapov; Olga K. Vikulova; Nadezhda Olegovna Lebedeva; Marina Vladimirovna Shestakova; +5 Authors

doi: 10.1134/s1022795416110065

pmid: 29372795

The analysis of association between type 2 diabetes and polymorphic markers in the CDKAL1 gene and in the HHEX/IDE locus

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Abstract

The increase in diabetes was noted at the turn of the 21st century. Patients with type 2 diabetes (T2DM) make up the majority of patients. Diabetes is a multifactorial disease. It arises from adverse effects of environmental factors on the body of genetically susceptible peoples. According to modern concepts, T2DM is a polygenic disease. Each of the involved genes contributes to the risk of developing of this disease. In our study, the association between polymorphic genetic markers rs7756992, rs9465871, rs7754840, and rs10946398 in the CDKAL1 gene and rs1111875 in the HHEX/IDE locus and T2DM in the Russian population were studied. Four hundred forty patients with type 2 diabetes and 264 healthy individuals without any signs of the disease were examined. The comparative analysis of distribution of genotypes and allele frequencies points to an association between polymorphic genetic markers rs7756992, rs9465871, and rs10946398 in the CDKAL1 gene and this disease. For the other polymorphic genetic markers (rs7754840 in the CDKAL1 gene and rs1111875 in the HHEX/IDE locus), no statistically significant associations are found. On the basis of these data, we can conclude that the CDKAL1 gene is associated with development of T2DM. For the HHEX/IDE locus, such an association is absent.

Related Organizations

Sechenov University
Russian Federation
Endocrinology Research Center
Russian Federation

Keywords

Genetic Markers, Homeodomain Proteins, Male, tRNA Methyltransferases, Polymorphism, Genetic, Diabetes Mellitus, Type 2, Genetic Loci, Humans, Female, Transcription Factors

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