Differential regulation of the insulin‐like growth factor II mRNA‐binding protein genes by architectural transcription factor HMGA2
Copyright policy )Differential regulation of the insulin‐like growth factor II mRNA‐binding protein genes by architectural transcription factor HMGA2
The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis. Little is known, however, about its downstream targets. We performed a search for genes of which expression is strongly altered during embryonic development in two HMGA2‐deficient mouse strains, which display a pygmy‐phenotype, as compared to wild‐type mice. We found that the insulin‐like growth factor II mRNA‐binding protein 2 gene (IMP2), but not its family members IMP1 and IMP3, was robustly downregulated in mutant E12.5 embryos. Furthermore, we show that wild‐type HMGA2 and its tumor‐specific truncated form have opposite effects on IMP2 expression. Our results clearly indicate that HMGA2 differentially regulates expression of IMP family members during embryogenesis.
- Katholieke Universiteit Leuven Belgium
- Maastricht University Netherlands
- Université Catholique de Louvain Belgium
- University of Medicine and Dentistry of New Jersey United States
- University of Leuven (KU Leuven) Belgium
Molecular Sequence Data, Embryonic and Fetal Development, Mice, Insulin-Like Growth Factor II, Animals, Humans, Amino Acid Sequence, RNA, Messenger, Insulin-like growth factor II, Conserved Sequence, DNA Primers, Mice, Knockout, Base Sequence, p62, HMGA2 Protein, hnRNP K homology-domain containing protein overexpressed in cancer, RNA-Binding Proteins, High mobility group A1, Peptide Fragments, Recombinant Proteins, Neoplasm Proteins, Gene Expression Regulation, VICKZ, Coding region determinant-binding protein, Sequence Alignment, Plasmids
Molecular Sequence Data, Embryonic and Fetal Development, Mice, Insulin-Like Growth Factor II, Animals, Humans, Amino Acid Sequence, RNA, Messenger, Insulin-like growth factor II, Conserved Sequence, DNA Primers, Mice, Knockout, Base Sequence, p62, HMGA2 Protein, hnRNP K homology-domain containing protein overexpressed in cancer, RNA-Binding Proteins, High mobility group A1, Peptide Fragments, Recombinant Proteins, Neoplasm Proteins, Gene Expression Regulation, VICKZ, Coding region determinant-binding protein, Sequence Alignment, Plasmids
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