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DNA Topoisomerase 1α Promotes Transcriptional Silencing of Transposable Elements through DNA Methylation and Histone Lysine 9 Dimethylation in Arabidopsis

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 03 Jul 2014 Germany, United States, Argentina English Publisher:Public Library of Science (PLoS)Journal:PLoS Genetics, volume 10, page e1004446 (eissn: 1553-7404, Copyright policy )Funded by:NIH | Genome-wide transcription..., NSF | Arabidopsis 2010: Transcr..., NSF | IGERT in Chemical Genomic... +1 projects
Authors: Shaofang Li; Shengben Li; Olga Pontes; Joseph R. Ecker; Michael O’Leary; Detlef Weigel; Brandon H. Le; +9 Authors

doi: 10.1371/journal.pgen.1004446

pmid: 24992598

pmc: PMC4080997

handle: 11336/14233 , 10900/57261

DNA Topoisomerase 1α Promotes Transcriptional Silencing of Transposable Elements through DNA Methylation and Histone Lysine 9 Dimethylation in Arabidopsis

Abstract

RNA-directed DNA methylation (RdDM) and histone H3 lysine 9 dimethylation (H3K9me2) are related transcriptional silencing mechanisms that target transposable elements (TEs) and repeats to maintain genome stability in plants. RdDM is mediated by small and long noncoding RNAs produced by the plant-specific RNA polymerases Pol IV and Pol V, respectively. Through a chemical genetics screen with a luciferase-based DNA methylation reporter, LUCL, we found that camptothecin, a compound with anti-cancer properties that targets DNA topoisomerase 1α (TOP1α) was able to de-repress LUCL by reducing its DNA methylation and H3K9me2 levels. Further studies with Arabidopsis top1α mutants showed that TOP1α silences endogenous RdDM loci by facilitating the production of Pol V-dependent long non-coding RNAs, AGONAUTE4 recruitment and H3K9me2 deposition at TEs and repeats. This study assigned a new role in epigenetic silencing to an enzyme that affects DNA topology.

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Keywords

570, Transcription, Genetic, Type I, Arabidopsis, 610, Epigenetica, QH426-470, Epigenesis, Genetic, Histones, Genetic, https://purl.org/becyt/ford/1.6, Genetics, Gene Silencing, https://purl.org/becyt/ford/1, Lysine, Human Genome, DNA Methylation, DNA Topoisomerases, Type I, Metilación, Mutation, DNA Transposable Elements, RNA, Long Noncoding, RNA, Long Noncoding, Silenciamiento, Transcription, DNA Topoisomerases, Epigenesis, Developmental Biology, Research Article

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
29
Top 10%
Top 10%
Top 10%
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