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Unravelling the effect of the E545K mutation on PI3Kα kinase

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2020 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Science, volume 11, pages 3,511-3,515 (issn: 2041-6520, eissn: 2041-6539, Copyright policy )Funded by:UKRI | Predicting drug-target bi..., UKRI | EPSRC Flagship Software -..., EC | HBP SGA2
Authors: Ioannis Galdadas; Francesco Luigi Gervasio; Zoe Cournia;

doi: 10.1039/c9sc05903b

pmid: 34703536

pmc: PMC8493679

Unravelling the effect of the E545K mutation on PI3Kα kinase

Abstract

The mechanism by which the cancer-causing E545K mutation may lead to PI3Kα activation is described in atomic-level detail.

Related Organizations
Keywords

Cancer development, Chemistry, 615, Hotspot mutation, E545K mutation, ddc: ddc:615

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
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17
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Average
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2
2
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Cancer Research