The generation of mid-infrared pulsed lasers was achieved in a Ho3+:YAG laser pumped gain-switched Cr2+:CdSe laser system with the shortest pulse duration of 4.15 ns. With a pump pulse duration of 50 ns and pump power of 2.7 W, the gain-switched Cr2+:CdSe laser achieved over 10 times pulse narrowing, obtaining the maximum peak power of 5.7 kW. The optical-to-optical conversion efficiency was 3.7%, which could be further improved with better crystal surface polishing quality. The laser central wavelength was measured to be 2.65 μm with a bandwidth (FWHM) of 50 nm. In addition, the parameter optimization for suppressing the pulse tail was discussed, while the long cavity and high output transmissivity contributed to obtaining the single-peak pulses.