A pre-flight analysis was conducted for the Mach 7 and Mach 10 X-43 cowl-closed configurations to evaluate three-dimensional flow-field effects on localized heating in the vicinity of the closed cowl flap and sidewall. First, engineering-level analyses based on documented laminar and turbulent surface heating database were used to estimate localized heating amplification factors to account for turbulent flow effects, corner flow effects and the presence of forebody boundary layer trip devices. These estimated factors were applied to 2-D computational predictions to develop surface heat loads. Second, thin-film gauge surface heating data were obtained for a Mach 10 cowl-closed configuration in a reflected shock tunnel at simulated flight conditions. Third, computational fluid dynamics (CFD) flow-field predictions were obtained at Mach 10 ground test conditions to provide comparisons with the engineering database predictions and experimental measurements. Similarly, a CFD solution was also obtained at Mach 7 flight conditions to provide qualitative comparisons with engineering predictions. The Mach 10 CFD predictions compare favorably with the experimental measurements and the engineering estimates for surface heating amplification on the closed cowl. However, experimental measurements were not of sufficient quantity on the sidewall surface to capture the highest localized heating rates, and also the Mach 10 CFD predictions suggest higher peak heating on the sidewall compared to the engineering estimates. Also, the Mach 7 CFD predictions indicate qualitative agreement with the database estimates in terms of flow-field structure and peak heating locations on the closed-cowl flap and sidewall surfaces.