Clinical Phenotype of an Italian Family with a New Mutation in the PRPF8 Gene
Copyright policy )Clinical Phenotype of an Italian Family with a New Mutation in the PRPF8 Gene
Purpose To report the clinical and functional characteristics of an autosomal dominant retinitis pigmentosa (ADRP) family with a novel point mutation (P2301S) in the PRPF8 gene. Methods PRPF8 gene analysis and complete ophthalmologic examination in an ADRP family. Results Clinical examination revealed the typical RP phenotype in all family members. Electroretinography showed preserved ERG photopic responses. Genetic analysis showed that the P2301S missense mutation segregated with the disease in all subjects. Conclusions Unlike previously reported families, the PRPF8 gene mutation in our family is associated with a mild phenotype in which cone function is partially preserved.
Male, RNA-Binding Proteins, DNA, Pedigree, Ophthalmoscopy, Phenotype, A D R P,; PRPF8 gene,; P2301S mutation, Italy, Mutation, Electroretinography, Humans, Female, Carrier Proteins, Retinitis Pigmentosa
Male, RNA-Binding Proteins, DNA, Pedigree, Ophthalmoscopy, Phenotype, A D R P,; PRPF8 gene,; P2301S mutation, Italy, Mutation, Electroretinography, Humans, Female, Carrier Proteins, Retinitis Pigmentosa
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