Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver
Copyright policy ) Zhenhua, Sui; Roberta B, Nowak; Andrea, Bacconi; Nancy E, Kim; Hui, Liu; Jie, Li; Amittha, Wickrema; +2 Authors
Zhenhua, Sui; Roberta B, Nowak; Andrea, Bacconi; Nancy E, Kim; Hui, Liu; Jie, Li; Amittha, Wickrema; Xiu-li, An; Velia M, Fowler;
Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver
Key Points Tmod3 deletion leads to reduced erythroid progenitors and impaired erythroblast survival, cell-cycle exit, and enucleation. Erythroblast-macrophage islands are reduced in the absence of Tmod3, which is required in both cell types for island formation.
- University of Chicago United States
- New York Blood Center United States
- Scripps Research Institute United States
Erythroid Precursor Cells, Male, Mice, Knockout, Erythroblasts, Cell Cycle, Gene Expression Regulation, Developmental, Apoptosis, Mice, Liver, Animals, Erythropoiesis, Female, Gene Deletion, Tropomodulin
Erythroid Precursor Cells, Male, Mice, Knockout, Erythroblasts, Cell Cycle, Gene Expression Regulation, Developmental, Apoptosis, Mice, Liver, Animals, Erythropoiesis, Female, Gene Deletion, Tropomodulin
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