Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure
Copyright policy )Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure
The objective of this study is to assess the risk of newly acquired RNA detection-proven SARS-CoV-2 infection after previous SARS-CoV-2 infection. This is a prospective study conducted from March to September 2020 in Barcelona, Spain. Healthcare workers caring for SARS-CoV-2 infected patients were divided in two cohorts: (a) previously RNA-proven SARS-CoV-2 infected cohort with mild symptoms (IC) and (b) healthy cohort (HC). Weekly SARS-CoV-2 RNA detection assays from nasopharyngeal swabs were performed. Serology status was assessed at the beginning and at the end of the study. Twenty participants were included in each group. The median age was 30 (IQR 27–34.75) years, and 55% were female. The median time of follow up was 49 (IQR 49–51) days. Fifteen out of 246 (6%) nasopharyngeal swab samples were positive for SARS-CoV-2, all in the IC. The percentage of participants in the IC with a probable newly acquired SARS-CoV-2 RNA-proven infection was 20% (95% IC 5.7–43.6%) at the end of the 7-week follow up period. The incidence reinfection rate was 28.6 (95% IC 7.8–73.2) cases per 1000 person-week. Despite detectable IgG antibodies against SARS-CoV-2 participants highly exposed to SARS-CoV-2 may develop a newly acquired SARS-CoV-2 RNA detection episode during the first months after the initial infection.
serology, Riscos per a la salut - Avaluació, Article, reinfection, genome amplification diagnostic assays, Malalties - Recaiguda, DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections, SALUD PÚBLICA::salud ambiental::salud laboral::riesgos profesionales, NAMED GROUPS::Persons::Occupational Groups::Health Personnel, ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus, Other subheadings::Other subheadings::Other subheadings::/prevention & control, Otros calificadores::Otros calificadores::Otros calificadores::/prevención & control, COVID-19 (Malaltia) - Prevenció, Personal sanitari - Salut i higiene, SARS-CoV-2, Natural immunity, DENOMINACIONES DE GRUPOS::personas::grupos profesionales::personal sanitario, Genome amplification diagnostic assays, natural immunity, Serology, Reinfection, PUBLIC HEALTH::Environmental Health::Occupational Health::Occupational Risks
serology, Riscos per a la salut - Avaluació, Article, reinfection, genome amplification diagnostic assays, Malalties - Recaiguda, DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections, SALUD PÚBLICA::salud ambiental::salud laboral::riesgos profesionales, NAMED GROUPS::Persons::Occupational Groups::Health Personnel, ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus, Other subheadings::Other subheadings::Other subheadings::/prevention & control, Otros calificadores::Otros calificadores::Otros calificadores::/prevención & control, COVID-19 (Malaltia) - Prevenció, Personal sanitari - Salut i higiene, SARS-CoV-2, Natural immunity, DENOMINACIONES DE GRUPOS::personas::grupos profesionales::personal sanitario, Genome amplification diagnostic assays, natural immunity, Serology, Reinfection, PUBLIC HEALTH::Environmental Health::Occupational Health::Occupational Risks
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