Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload
Copyright policy )Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload
AbstractLeft ventricular hypertrophy (LVH) ultimately leads to heart failure in conditions of increased cardiac pre- or afterload. The bone-derived phosphaturic and sodium-conserving hormone fibroblast growth factor-23 (FGF23) and its co-receptor Klotho have been implicated in the development of uremic LVH. Using transverse aortic constriction (TAC) in gene-targeted mouse models, we examine the role of Fgf23 and Klotho in cardiac hypertrophy and dysfunction induced by pressure overload. TAC profoundly increases serum intact Fgf23 due to increased cardiac and bony Fgf23 transcription and downregulation of Fgf23 cleavage. Aldosterone receptor blocker spironolactone normalizes serum intact Fgf23 levels after TAC by reducing bony Fgf23 transcription. Notably, genetic Fgf23 or Klotho deficiency does not influence TAC-induced hypertrophic remodelling, LV functional impairment, or LV fibrosis. Despite the profound, aldosterone-mediated increase in circulating intact Fgf23 after TAC, our data do not support an essential role of Fgf23 or Klotho in the pathophysiology of pressure overload-induced cardiac hypertrophy.
- FWF Austrian Science Fund Austria
- University of Veterinary Medicine Vienna Austria
- University of Vienna Austria
CHRONIC KIDNEY-DISEASE, 305907 Medical statistics, PARATHYROID-HORMONE, Heart failure, Blood Pressure, Cardiomegaly, Spironolactone, Article, 301109 Pathophysiologie, Gene Knockout Techniques, Mice, LEFT-VENTRICULAR HYPERTROPHY, D-RECEPTOR, Animals, 301109 Pathophysiology, CARDIAC-HYPERTROPHY, Aldosterone, Klotho Proteins, SOLUBLE KLOTHO, Glucuronidase, Mice, Knockout, CARDIOVASCULAR HEALTH, 305907 Medizinische Statistik, Fibrosis, FIBROBLAST GROWTH FACTOR-23, Fibroblast Growth Factors, Cardiac hypertrophy, Disease Models, Animal, Fibroblast Growth Factor-23, Cardiovascular diseases, Gene Expression Regulation, Hypertension, VITAMIN-D METABOLISM, GLUCOSE-HOMEOSTASIS, 302014 Endokrinologie, Disease Susceptibility, 302014 Endocrinology, Biomarkers, Signal Transduction
CHRONIC KIDNEY-DISEASE, 305907 Medical statistics, PARATHYROID-HORMONE, Heart failure, Blood Pressure, Cardiomegaly, Spironolactone, Article, 301109 Pathophysiologie, Gene Knockout Techniques, Mice, LEFT-VENTRICULAR HYPERTROPHY, D-RECEPTOR, Animals, 301109 Pathophysiology, CARDIAC-HYPERTROPHY, Aldosterone, Klotho Proteins, SOLUBLE KLOTHO, Glucuronidase, Mice, Knockout, CARDIOVASCULAR HEALTH, 305907 Medizinische Statistik, Fibrosis, FIBROBLAST GROWTH FACTOR-23, Fibroblast Growth Factors, Cardiac hypertrophy, Disease Models, Animal, Fibroblast Growth Factor-23, Cardiovascular diseases, Gene Expression Regulation, Hypertension, VITAMIN-D METABOLISM, GLUCOSE-HOMEOSTASIS, 302014 Endokrinologie, Disease Susceptibility, 302014 Endocrinology, Biomarkers, Signal Transduction
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