Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome
Copyright policy )Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome
The aim of the study was to evaluate the levels of physical activity in individuals with primary Sjögren's syndrome (PSS) and its relationship to the clinical features of PSS. To this cross-sectional study, self-reported levels of physical activity from 273 PSS patients were measured using the International Physical Activity Questionnaire-short form (IPAQ-SF) and were compared with healthy controls matched for age, sex and body mass index. Fatigue and other clinical aspects of PSS including disease status, dryness, daytime sleepiness, dysautonomia, anxiety and depression were assessed using validated tools. Individuals with PSS had significantly reduced levels of physical activity [median (interquartile range, IQR) 1572 (594-3158) versus 3708 (1732-8255) metabolic equivalent of task (MET) × min/week, p < 0.001], but similar levels of sedentary activity [median (IQR) min 300 (135-375) versus 343 (223-433) (MET) × min/week, p = 0.532] compared to healthy individuals. Differences in physical activity between PSS and controls increased at moderate [median (IQR) 0 (0-480) versus 1560 (570-3900) MET × min/week, p < 0.001] and vigorous intensities [median (IQR) 0 (0-480) versus 480 (0-1920) MET × min/week, p < 0.001]. Correlation analysis revealed a significant association between physical activity and fatigue, orthostatic intolerance, depressive symptoms and quality of life. Sedentary activity did not correlate with fatigue. Stepwise linear regression analysis identified symptoms of depression and daytime sleepiness as independent predictors of levels of physical activity. Physical activity is reduced in people with PSS and is associated with symptoms of depression and daytime sleepiness. Sedentary activity is not increased in PSS. Clinical care teams should explore the clinical utility of targeting low levels of physical activity in PSS.
- Newcastle University Malaysia
- Newcastle University United Kingdom
- Universidade de São Paulo Brazil
- University of Leeds
- University of Leeds United Kingdom
Primary Sjogren's syndrome, Male, Immunology, Primary Sjögren’s syndrome, Observational Research, A900, Rheumatology, Immunology and Allergy, Humans, Exercise, Fatigue, Aged, Patient-reported outcomes, Physical activity, Middle Aged, B900, Cross-Sectional Studies, Sjogren's Syndrome, Quality of Life, Patient registry, Female, Sedentary Behavior
Primary Sjogren's syndrome, Male, Immunology, Primary Sjögren’s syndrome, Observational Research, A900, Rheumatology, Immunology and Allergy, Humans, Exercise, Fatigue, Aged, Patient-reported outcomes, Physical activity, Middle Aged, B900, Cross-Sectional Studies, Sjogren's Syndrome, Quality of Life, Patient registry, Female, Sedentary Behavior
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).19 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!