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Science Signaling
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Science Signaling
Article . 2014 . Peer-reviewed
Data sources: Crossref
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The autoinhibitory C-terminal SH2 domain of phospholipase C–γ2 stabilizes B cell receptor signalosome assembly

Authors: Joshua D. Milner; Guangping Sun; Jing Wang; Susan K. Pierce; Haewon Sohn;

The autoinhibitory C-terminal SH2 domain of phospholipase C–γ2 stabilizes B cell receptor signalosome assembly

Abstract

The immune disorder PLAID is found to be the result of destabilization of B cell receptor complexes due to loss of an autoinhibitory domain in phospholipase C–γ2.

Keywords

Analysis of Variance, Microscopy, Confocal, Phospholipase C gamma, Lipid Bilayers, Immunologic Deficiency Syndromes, Intracellular Signaling Peptides and Proteins, Receptors, Antigen, B-Cell, Protein-Tyrosine Kinases, Flow Cytometry, Microscopy, Fluorescence, Multiprotein Complexes, COS Cells, Chlorocebus aethiops, Agammaglobulinaemia Tyrosine Kinase, Animals, Humans, Syk Kinase, Calcium, Phosphorylation, Signal Transduction

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    34
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
34
Top 10%
Top 10%
Top 10%
bronze