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Neuronal activity moves protein palmitoylation into the synapse

Name: Neuronal activity moves protein palmitoylation into the synapse
Creator: Matthew B. Dalva
Keywords: Neurons, 0301 basic medicine, 0303 health sciences, Lipoylation, 4. Education, Intracellular Signaling Peptides and Proteins, Reviews, Membrane Proteins, Dendrites, 16. Peace & justice

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 13 Jul 2009Publisher:Rockefeller University PressJournal:Journal of Cell Biology, volume 186, pages 7-9 (issn: 0021-9525, eissn: 1540-8140,

Authors: Matthew B. Dalva;

doi: 10.1083/jcb.200906101

pmid: 19596846

pmc: PMC2712999

Neuronal activity moves protein palmitoylation into the synapse

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Abstract

Many neuronal proteins undergo lipid modification that regulates their function and subcellular localization. One such modification is palmitoylation, which is mediated by a large class of protein palmitoyl acyltransferases (PATs). Now, a paper in this issue (Noritake et al. 2009. J. Cell Biol. doi:10.1083/jcb.200903101) demonstrates that the localization of the PAT DHHC2 is regulated by neuronal activity and thereby selectively controls the palmitoylation and subsequent accumulation of specific proteins in the synapse.

Related Organizations

University of Pennsylvania
United States

Keywords

Neurons, Lipoylation, Intracellular Signaling Peptides and Proteins, Reviews, Membrane Proteins, Dendrites, Models, Biological, Protein Transport, Acetyltransferases, Synapses, Humans, Disks Large Homolog 4 Protein

11 Research products, page 1 of 2

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