The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription
Copyright policy )The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription
ABSTRACT The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins involved in infectivity, replication, and transformation. We report in this study the characterization of a novel viral protein encoded by the complementary strand of the HTLV-1 RNA genome. This protein, designated HBZ (for HTLV-1 bZIP factor), contains a N-terminal transcriptional activation domain and a leucine zipper motif in its C terminus. We show here that HBZ is able to interact with the bZIP transcription factor CREB-2 (also called ATF-4), known to activate the HTLV-1 transcription by recruiting the viral trans -activator Tax on the Tax-responsive elements (TxREs). However, we demonstrate that the HBZ/CREB-2 heterodimers are no more able to bind to the TxRE and cyclic AMP response element sites. Taking these findings together, the functional inactivation of CREB-2 by HBZ is suggested to contribute to regulation of the HTLV-1 transcription. Moreover, the characterization of a minus-strand gene protein encoded by HTLV-1 has never been reported until now.
Transcription Factors/chemistry/genetics/metabolism, Gene Expression Regulation, Viral, 570, Transcription, Genetic, Molecular Sequence Data, Down-Regulation, Expression, DNA-Binding Proteins/chemistry/genetics, Biochimie, biophysique & biologie moléculaire, RNA, Complementary, [SDV.CAN] Life Sciences [q-bio]/Cancer, Animals, RNA, Complementary/genetics, Amino Acid Sequence, rétrovirologie, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Binding Protein Creb, Transactivation, Activating Transcription Factor 4; Amino Acid Sequence; Animals; Basic-Leucine Zipper Transcription Factors; COS Cells; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/genetics; Down-Regulation; G-Box Binding Factors; Gene Expression Regulation, Viral; Human T-lymphotropic virus 1/genetics; Molecular Sequence Data; RNA, Complementary/genetics; RNA, Viral/genetics; Transcription Factors/chemistry; Transcription Factors/genetics; Transcription, Genetic, Human T-lymphotropic virus 1, antisens, Dna-Binding, Human T-lymphotropic virus 1/genetics, Life sciences, Activating Transcription Factor 4, Camp Response Element, [SDV] Life Sciences [q-bio], DNA-Binding Proteins, RNA, Viral/genetics, Htlv-I, Basic-Leucine Zipper Transcription Factors, G-Box Binding Factors, HTLV-1, 21-Base-Pair Repeats, COS Cells, Sciences du vivant, RNA, Viral, Molecular-Cloning, I Tax Protein, transcription, Enhancer, Biochemistry, biophysics & molecular biology, Transcription Factors
Transcription Factors/chemistry/genetics/metabolism, Gene Expression Regulation, Viral, 570, Transcription, Genetic, Molecular Sequence Data, Down-Regulation, Expression, DNA-Binding Proteins/chemistry/genetics, Biochimie, biophysique & biologie moléculaire, RNA, Complementary, [SDV.CAN] Life Sciences [q-bio]/Cancer, Animals, RNA, Complementary/genetics, Amino Acid Sequence, rétrovirologie, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Binding Protein Creb, Transactivation, Activating Transcription Factor 4; Amino Acid Sequence; Animals; Basic-Leucine Zipper Transcription Factors; COS Cells; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/genetics; Down-Regulation; G-Box Binding Factors; Gene Expression Regulation, Viral; Human T-lymphotropic virus 1/genetics; Molecular Sequence Data; RNA, Complementary/genetics; RNA, Viral/genetics; Transcription Factors/chemistry; Transcription Factors/genetics; Transcription, Genetic, Human T-lymphotropic virus 1, antisens, Dna-Binding, Human T-lymphotropic virus 1/genetics, Life sciences, Activating Transcription Factor 4, Camp Response Element, [SDV] Life Sciences [q-bio], DNA-Binding Proteins, RNA, Viral/genetics, Htlv-I, Basic-Leucine Zipper Transcription Factors, G-Box Binding Factors, HTLV-1, 21-Base-Pair Repeats, COS Cells, Sciences du vivant, RNA, Viral, Molecular-Cloning, I Tax Protein, transcription, Enhancer, Biochemistry, biophysics & molecular biology, Transcription Factors
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