To identify the most efficient growing medium for root and shoot development in stem cuttings of pomegranate cv. ‘Phulearakta’ under arid conditions, a greenhouse experiment was conducted in randomized complete block design with three replications during 2014-15 at ICAR-CIAH, Bikaner. About 15-20 cm long hard wood cuttings, 0.5-1.0 cm diameter and having three to four buds were separated from the healthy trees and planted in mid-January. Detached cuttings were treated with 2500 ppm of IBA (3- Indole butyric acid) using quick dip technique (for 5 seconds) and planted in five rooting substrates i.e.sand, vermiculite, perlite, cocopeat and garden soil (control) alone and in combination at 1:1 (v/v). The response of perlite + vermiculite medium was best in terms of rooting (82.33 per cent), number of roots (32.67 per cutting), fresh and dry weight of roots (0.61 mg and 2.08 mg), shoots per cutting (80.33) and survival (76.0 per cent) than the other medium used. Vermiculite + Coco peat 1:1 (v/v) combination also resulted in rooting in more than 80 per cent of cuttings whereas cuttings raised in garden soil and sand showed very low rooting. Based on the findings, it appears that Perlite + vermiculite 1:1 (v/v) and vermiculite + cocopeat may be appropriate alternatives to the conventially used substrate, i.e., garden soil for the better rooting and establishment of pomegranate cultivar 'PhuleArakta' cuttings.