Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status
Copyright policy )Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status
Ribonucleotide reductase catalyzes the conversion of ribonucleotide diphosphates to deoxyribonucleotide diphosphates. The functional enzyme consists of two subunits - one large (RRM1) and one small (RRM2 or RRM2b) subunit. Expression levels of each subunit have been implicated in prognostic outcomes in several different types of cancers.Immunohistochemistry for RRM1 and RRM2 was performed on a lung cancer tissue microarray (TMA) and analyzed. 326 patients from the microarray were included in this study.In non-small cell lung cancer (NSCLC), RRM2 expression was strongly predictive of disease-specific survival in women, non-smokers and former smokers who had quit at least 10 years prior to being diagnosed with lung cancer. Higher expression was associated with worse survival. This was not the case for men, current smokers and those who had stopped smoking for shorter periods of time. RRM1 was not predictive of survival outcomes in any subset of the patient group.RRM2, but not RRM1, is a useful predictor of survival outcome in certain subsets of NSCLC patients.
- University of California, Los Angeles United States
- UCLA Jonsson Comprehensive Cancer Center United States
- UCLA Health United States
- University of California, San Francisco United States
Male, Lung Neoplasms, Ribonucleoside Diphosphate Reductase, General Science & Technology, Science, Oncology and Carcinogenesis, Sex Factors, Carcinoma, Non-Small-Cell Lung, Tobacco, 2.1 Biological and endogenous factors, Humans, Aetiology, Non-Small-Cell Lung, Lung, Cancer, Aged, Biomedical and Clinical Sciences, Tobacco Smoke and Health, Tumor Suppressor Proteins, Lung Cancer, Carcinoma, Q, Smoking, R, Middle Aged, Prognosis, Survival Rate, Women's Health, Medicine, Female, Research Article
Male, Lung Neoplasms, Ribonucleoside Diphosphate Reductase, General Science & Technology, Science, Oncology and Carcinogenesis, Sex Factors, Carcinoma, Non-Small-Cell Lung, Tobacco, 2.1 Biological and endogenous factors, Humans, Aetiology, Non-Small-Cell Lung, Lung, Cancer, Aged, Biomedical and Clinical Sciences, Tobacco Smoke and Health, Tumor Suppressor Proteins, Lung Cancer, Carcinoma, Q, Smoking, R, Middle Aged, Prognosis, Survival Rate, Women's Health, Medicine, Female, Research Article
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