RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling
Copyright policy )RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling
Key Points Overexpression of RUNX1 and its target NF-E2 is not specific for PV but is also seen in polycythemias due to augmented hypoxia sensing. Elevated levels of RUNX1 and NF-E2 are not specific for primary polycythemias, as these are not present in PFCP.
- Palacký University, Olomouc Czech Republic
- University of Utah United States
- United States Department of Veterans Affairs United States
Myeloproliferative Disorders, Mice, Transgenic, Polycythemia, Hypoxia-Inducible Factor 1, alpha Subunit, Cell Hypoxia, Mice, Gene Expression Regulation, NF-E2 Transcription Factor, p45 Subunit, Core Binding Factor Alpha 2 Subunit, Mutation, Leukocytes, Mononuclear, Animals, Humans, Erythropoietin, Granulocytes, Signal Transduction
Myeloproliferative Disorders, Mice, Transgenic, Polycythemia, Hypoxia-Inducible Factor 1, alpha Subunit, Cell Hypoxia, Mice, Gene Expression Regulation, NF-E2 Transcription Factor, p45 Subunit, Core Binding Factor Alpha 2 Subunit, Mutation, Leukocytes, Mononuclear, Animals, Humans, Erythropoietin, Granulocytes, Signal Transduction
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