Starvation promotes concerted modulation of appetitive olfactory behavior via parallel neuromodulatory circuits
Copyright policy )Starvation promotes concerted modulation of appetitive olfactory behavior via parallel neuromodulatory circuits
The internal state of an organism influences its perception of attractive or aversive stimuli and thus promotes adaptive behaviors that increase its likelihood of survival. The mechanisms underlying these perceptual shifts are critical to our understanding of how neural circuits support animal cognition and behavior. Starved flies exhibit enhanced sensitivity to attractive odors and reduced sensitivity to aversive odors. Here, we show that a functional remodeling of the olfactory map is mediated by two parallel neuromodulatory systems that act in opposing directions on olfactory attraction and aversion at the level of the first synapse. Short neuropeptide F sensitizes an antennal lobe glomerulus wired for attraction, while tachykinin (DTK) suppresses activity of a glomerulus wired for aversion. Thus we show parallel neuromodulatory systems functionally reconfigure early olfactory processing to optimize detection of nutrients at the risk of ignoring potentially toxic food resources.
- University of California, San Diego United States
- University of California, San Francisco United States
- University of California, San Diego United States
- Trinity College Dublin Ireland
substance P, Starvation (mesh), Drosophila Proteins (mesh), neuroscience, Olfactory Perception (mesh), 31 Biological sciences (for-2020), Animals (mesh), Drosophila Proteins, Biology (General), 32 Biomedical and Clinical Sciences (for-2020), Neurosciences (rcdc), Appetitive Behavior, D. melanogaster, Drosophila melanogaster (mesh), Q, R, Olfactory Pathways, Biological Sciences, 3209 Neurosciences (for-2020), Drosophila melanogaster, Olfactory Pathways (mesh), Medicine, Tachykinins (mesh), Behavioral and Social Science (rcdc), olfaction, 570, insulin, QH301-705.5, Science, Appetitive Behavior (mesh), 0601 Biochemistry and Cell Biology (for), Basic Behavioral and Social Science, 42 Health sciences (for-2020), Tachykinins, Behavioral and Social Science, Animals, 31 Biological Sciences (for-2020), Neuropeptides (mesh), Biomedical and Clinical Sciences, Neuropeptides, Neurosciences, Health sciences, Olfactory Perception, 32 Biomedical and clinical sciences (for-2020), Starvation, Biochemistry and Cell Biology, RNA-seq, Basic Behavioral and Social Science (rcdc), two-photon imaging, sNPF, Neuroscience
substance P, Starvation (mesh), Drosophila Proteins (mesh), neuroscience, Olfactory Perception (mesh), 31 Biological sciences (for-2020), Animals (mesh), Drosophila Proteins, Biology (General), 32 Biomedical and Clinical Sciences (for-2020), Neurosciences (rcdc), Appetitive Behavior, D. melanogaster, Drosophila melanogaster (mesh), Q, R, Olfactory Pathways, Biological Sciences, 3209 Neurosciences (for-2020), Drosophila melanogaster, Olfactory Pathways (mesh), Medicine, Tachykinins (mesh), Behavioral and Social Science (rcdc), olfaction, 570, insulin, QH301-705.5, Science, Appetitive Behavior (mesh), 0601 Biochemistry and Cell Biology (for), Basic Behavioral and Social Science, 42 Health sciences (for-2020), Tachykinins, Behavioral and Social Science, Animals, 31 Biological Sciences (for-2020), Neuropeptides (mesh), Biomedical and Clinical Sciences, Neuropeptides, Neurosciences, Health sciences, Olfactory Perception, 32 Biomedical and clinical sciences (for-2020), Starvation, Biochemistry and Cell Biology, RNA-seq, Basic Behavioral and Social Science (rcdc), two-photon imaging, sNPF, Neuroscience
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