Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y
Copyright policy )Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y
Neuropeptide Y (NPY) is a potent orexigenic peptide that is implicated in the feeding response to a variety of stimuli. The current studies employed mice lacking NPY (Npy-/-) and their wild-type (Npy+/+) littermates to investigate the role of this peptide in the feeding response to circadian and palatability cues. To investigate the response to a circadian stimulus, we assessed food intake during the 4-h period following dark onset, a time of day characterized by maximal rates of food consumption. Compared to Npy+/+ controls, intake of Npy-/- mice was reduced by 33% during this period (0.6+/-0.1g versus 0.9+/-0.1g; p
- University of Cincinnati United States
- University of Washington United States
- University System of Ohio United States
- University of Mary United States
- Howard Hughes Medical Institute United States
Mice, Knockout, Eating, Mice, Animals, Neuropeptide Y, Feeding Behavior, Food Deprivation, Circadian Rhythm
Mice, Knockout, Eating, Mice, Animals, Neuropeptide Y, Feeding Behavior, Food Deprivation, Circadian Rhythm
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