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Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila

descriptionPublicationkeyboard_double_arrow_right Article 08 Jan 2015 English Publisher:American Society of HematologyJournal:Blood, volume 125, pages 336-345 (issn: 0006-4971, eissn: 1528-0020,

Authors: Sergey A. Sinenko; Zachary J. Reitman; Hai Yan; Eric P. Spana;

doi: 10.1182/blood-2014-05-577940

pmid: 25398939

pmc: PMC4287640

Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila

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Abstract

Key PointsHomologs to cancer-derived IDH1 and IDH2 mutants produce D-2HG and drive expansion of Drosophila blood cells. In flies, mutant Idh interacts with genes that regulate reduced nicotinamide adenine dinucleotide phosphate, reactive oxygen species, and apoptosis.

Related Organizations

Duke University
United States
Duke Medical Center
United States

Keywords

Leukemia, Sequence Homology, Amino Acid, Immunoblotting, Isocitrate Dehydrogenase, Animals, Genetically Modified, Glutarates, Disease Models, Animal, Drosophila melanogaster, Animals, Humans

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	26
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