The p38 Pathway Regulates Oxidative Stress Tolerance by Phosphorylation of Mitochondrial Protein IscU
Copyright policy )The p38 Pathway Regulates Oxidative Stress Tolerance by Phosphorylation of Mitochondrial Protein IscU
The p38 pathway is an evolutionarily conserved signaling pathway that responds to a variety of stresses. However, the underlying mechanisms are largely unknown. In the present study, we demonstrate that p38b is a major p38 MAPK involved in the regulation of oxidative stress tolerance in addition to p38a and p38c in Drosophila. We further show the importance of MK2 as a p38-activated downstream kinase in resistance to oxidative stresses. Furthermore, we identified the iron-sulfur cluster scaffold protein IscU as a new substrate of MK2 both in Drosophila cells and in mammalian cells. These results imply a new mechanistic connection between the p38 pathway and mitochondria iron-sulfur clusters.
- Ministry of Natural Resources of China China (People's Republic of)
- University of Toronto Canada
- State Oceanic Administration China (People's Republic of)
- Third Institute of Oceanography China (People's Republic of)
- Xiamen University China (People's Republic of)
Iron-Sulfur Proteins, MAP Kinase Signaling System, Molecular Sequence Data, Protein Serine-Threonine Kinases, Gene Expression Regulation, Enzymologic, Animals, Genetically Modified, Mitochondrial Proteins, Animals, Drosophila Proteins, Humans, Amino Acid Sequence, Phosphorylation, Mammals, Aconitate Hydratase, Electron Transport Complex I, Sequence Homology, Amino Acid, Intracellular Signaling Peptides and Proteins, Proteins, Mitochondria, Oxidative Stress, Drosophila melanogaster, HEK293 Cells, Oxidative stress, Sulfur, Protein Binding
Iron-Sulfur Proteins, MAP Kinase Signaling System, Molecular Sequence Data, Protein Serine-Threonine Kinases, Gene Expression Regulation, Enzymologic, Animals, Genetically Modified, Mitochondrial Proteins, Animals, Drosophila Proteins, Humans, Amino Acid Sequence, Phosphorylation, Mammals, Aconitate Hydratase, Electron Transport Complex I, Sequence Homology, Amino Acid, Intracellular Signaling Peptides and Proteins, Proteins, Mitochondria, Oxidative Stress, Drosophila melanogaster, HEK293 Cells, Oxidative stress, Sulfur, Protein Binding
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