Nck influences preosteoblastic/osteoblastic migration and bone mass
Copyright policy )Nck influences preosteoblastic/osteoblastic migration and bone mass
Significance Osteoporosis is a major health problem worldwide, as the aging population is soaring. However, molecules involved in the regulation of bone remodeling are still incompletely understood. Nck (noncatalytic region of tyrosine kinase) is an adaptor molecule linking cytoskeleton and cell motility. We now identify that Nck regulates cell migration in vitro as well as in vivo and regulates bone mass via bone formation activity. Nck positively regulates repair of bone injury. This discovery provides a unique insight into the understanding of bone remodeling.
Mice, Knockout, Oncogene Proteins, Wound Healing, Osteoblasts, Skull, Organ Size, Bone and Bones, Radiography, Cell Movement, Osteogenesis, Gene Knockdown Techniques, Insulin Receptor Substrate Proteins, Animals, Bone Resorption, Insulin-Like Growth Factor I, Cell Shape, Cells, Cultured, Adaptor Proteins, Signal Transducing, Protein Binding
Mice, Knockout, Oncogene Proteins, Wound Healing, Osteoblasts, Skull, Organ Size, Bone and Bones, Radiography, Cell Movement, Osteogenesis, Gene Knockdown Techniques, Insulin Receptor Substrate Proteins, Animals, Bone Resorption, Insulin-Like Growth Factor I, Cell Shape, Cells, Cultured, Adaptor Proteins, Signal Transducing, Protein Binding
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).28 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!