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Haptoglobin dampens endotoxin‐induced inflammatory effects both in vitro and in vivo

descriptionPublicationkeyboard_double_arrow_right Article 25 Jan 2005 English Publisher:WileyJournal:Immunology, volume 114, pages 263-271 (issn: 0019-2805, eissn: 1365-2567,

Authors: Jan Ceuppens; Ahmad Kasran; Heinz Baumann; Frank G. Berger; M. Arredouani; Jeroen Vanoirbeek;

doi: 10.1111/j.1365-2567.2004.02071.x

pmid: 15667571

pmc: PMC1782073

Haptoglobin dampens endotoxin‐induced inflammatory effects both in vitro and in vivo

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Abstract

SummaryWe report that haptoglobin, an acute‐phase protein produced by liver cells in response to interleukin‐6 (IL‐6), can modulate the inflammatory response induced by endotoxins. We provide evidence that haptoglobin has the ability to selectively antagonize lipopolysaccharide (LPS) effects in vitro by suppressing monocyte production of tumour necrosis factor‐α, IL‐10 and IL‐12, while it fails to inhibit the production of IL‐6, IL‐8 and IL‐1 receptor antagonist. In two animal models of LPS‐induced bronchopulmonary hyperreactivity and endotoxic shock, haptoglobin knockout mice were more sensitive to LPS effects compared to their wild‐type counterparts. The present data suggest that haptoglobin regulates monocyte activation following LPS stimulation. The increase in haptoglobin levels during an acute‐phase reaction may generate a feedback effect which dampens the severity of cytokine release and protects against endotoxin‐induced effects.

Related Organizations

Université Catholique de Louvain
Belgium
University of South Carolina Lancaster
United States
Roswell Park Cancer Institute
United States
KU Leuven
Belgium

Keywords

Lipopolysaccharides, Mice, Knockout, Haptoglobins, Lipopolysaccharide Receptors, Flow Cytometry, Shock, Septic, Monocytes, Mice, Inbred C57BL, Mice, Depression, Chemical, Models, Animal, Animals, Cytokines, Humans, Bronchial Hyperreactivity, Acute-Phase Reaction, Cells, Cultured

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Haptoglobin
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