With the start up of West–East Natural Gas Transmission Project, the construction of natural gas-pipeline will enter on a new era in China. The development tendency will be towards large-diameter, high-pressure and long-distance for natural gas-pipelines. Correspondingly, the life cycle cost of natural gas-pipeline networks is increasing gradually. The mainline system is a vital part of natural gas network systems. The investment required for the mainline system is enormous, usually accounting for 80% of the total investment for this system. In general, the investment required for a gas-pipeline depends on its operating parameters. Therefore, based on the characteristics of gas networks, optimization for investment becomes indispensable to gas networks design. A comprehensive and optimal mathematic model of a gas networks system is established in this paper which considers all the factors influencing the total investment of a gas networks system (e.g. pipe diameter, thickness, pressure, length, compression ratio, etc). From the standpoint of the characteristics of a model comprising both continuous and discrete variables, a new methodology, rank-optimization, is presented. On the basis of this model, a simple and visual high-pressure networks optimization program has been compiled. Furthermore, the developed optimization program has been applied to a practical project and the effects of operating parameters on the total investment have been analyzed. The simulation model in this paper is shown to be an effective method to solve optimization on mainline system in high-pressure gas networks.