Evidence for Sex Transformation of Germline Cells in Ovarian Tumor Mutants of Drosophila
Copyright policy )Evidence for Sex Transformation of Germline Cells in Ovarian Tumor Mutants of Drosophila
Mutations at a few genetic loci in Drosophila cause ovarian tumors with hundreds of poorly differentiated germ cells. We examined several of these mutants to test the hypothesis that such ovarian tumors contain sex-transformed cells. By testing for expression of male germline traits, we determined that partial germline sex transformation occurs in otu, snf, Sxlfs, and bam ovarian tumors. Thus these genes are likely to be required for proper establishment of germline sexual identity.
- Stanford University United States
- Case Western Reserve University United States
- University of Geneva Switzerland
Germ Cells/physiology, Male, Ovarian Neoplasms, Sex Determination Analysis, Drosophila/genetics, Ovarian Neoplasms/genetics, Germ Cells, Tubulin, Mutation, Animals, Drosophila, Female, Tubulin/genetics
Germ Cells/physiology, Male, Ovarian Neoplasms, Sex Determination Analysis, Drosophila/genetics, Ovarian Neoplasms/genetics, Germ Cells, Tubulin, Mutation, Animals, Drosophila, Female, Tubulin/genetics
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