A decrement in the strength of the meaning of a word after rapid repetition of that word has been called "semantic satiation." This study asked whether this "satiation" might be produced by presemantic acoustic adaptation. Category words were utilized to prime the meaning of target words. The adaptation or "satiation" procedure, 30 rapid repetitions of the primes, was compared with a control condition of 3 repetitions. Participants listened to a series of prime words, each repeated by either the same speaker or many speakers, and then made semantic decisions on target words. When all the repetitions of a prime word are produced by the same speaker, presemantic and semantic repetitions are confounded. When the repetitions are produced by different speakers, presemantic acoustic repetition is abolished. A semantic decrement was detected with single-speaker, but not with multiple-speaker, repetitions of prime words. This study concluded that the semantic "satiation" observed here was a decrement in the activation level of semantic representations induced by presemantic acoustic adaptation.