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Alternative Splicing of FOXP3—Virtue and Vice

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 13 Mar 2018Publisher:Frontiers Media SAJournal:Frontiers in Immunology, volume 9 (eissn: 1664-3224, Copyright policy )Funded by:DFG | Liver inflammation: infec..., DFG | Proteolysis as a Regulato...
Authors: Reiner K. W. Mailer; Reiner K. W. Mailer;

doi: 10.3389/fimmu.2018.00530

pmid: 29593749

pmc: PMC5859138

Alternative Splicing of FOXP3—Virtue and Vice

Abstract

FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.

Related Organizations
Keywords

FOXP3, Immunology, isoform, Forkhead Transcription Factors, Exons, RC581-607, alternative splicing, Alternative Splicing, FOXP3Δ2Δ7, FOXP3Δ2, Neoplasms, Animals, Humans, Protein Isoforms, Immunologic diseases. Allergy, Treg cells

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 63
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
63
Top 1%
Top 10%
Top 10%
Green
gold