The Scripps Institution of Oceanography Benthic Invertebrate Collection (SIO-BIC) is a research repository with extensive holdings from deep-sea environments (>1,000 m), chemosynthetic ecosystems (hydrothermal vents, hydrocarbon seeps, whale falls), Antarctica, and the eastern Pacific. Materials have been collected through a range of techniques, from intertidal hand collecting and SCUBA to trawls and deep-sea submersibles.SIO-BIC contains more than 700 type lots and considerable material properly preserved for genomic studies (95% ethanol and ultracold storage). Multiple preparation types are often available for each lot (e.g., fluid voucher, ethanol subsample, dry material). The searchable electronic database, including a map search feature and specimen images, is updated weekly and publicly accessible online at http://tinyurl.com/siobic.SIO-BIC supports scientific research by providing specimens for study of the taxonomy, biogeography, and evolution of benthic invertebrates, including the description of many new species. Specimens are available for examination at Scripps and for loan to researchers at recognized institutions worldwide, consistent with our loan policies. Collection staff and materials also support education and public outreach via undergraduate and graduate classes, school programs, guest lectures, artist collaborations, and exhibits and events at the Birch Aquarium.