Background. Optimized preventive approaches concerning the development of comorbidity in the patients with overweight of various degree is a topical issue of medical science. Efficiency of such approaches depends on a whole range of pathogenic factors related to metabolic complications caused by obesity — the basis for comorbidity development, and determination of those markers which are the most information valuable as for their development. The changes observed in adipokine-cytokine system (marked with blood fractalkine, clusterin, vaspin, omentin contents) present some of these factors and associated with them alterations of free fatty acid metabolism as well. Nevertheless, the above mentioned markers are not determined in the most medical centers. Therefore, it is reasonable to determine the information value of the common risk criteria for the development of metabolic complications related to the above mentioned processes. However, no research concerning information value of these both criteria to assess the changes in adipokine-cytokine system and associated with them disorders of metabolism of free fatty acids in representatives of Ukrainian population has not been done yet. Objective. To assess information value of such criteria of abdominal obesity as waist circumference and waist circumference/hip circumference regarding the development of local inflammation of adipose tissue, systemic low intensity inflammation in the body, changes in secretory function of adipose tissue and metabolic features in city residents representing Ukrainian population. Material and methods. 250 indivi­duals aged 65.48 ± 11.86 years were examined, the contents of circulating fractalkine, clusterin, vaspin, omentin and leptin were determined by enzyme immunoassay; content of free fatty acids was determined by Duncombe’s method. The nature of correlations of the above mentioned parameters with waist circumference and hip circumference, waist circumference/hip circumfe­rence index was assessed. The nature of significant differences of these parameters in case of abdominal obesity and with no evidence of it was revealed considering the waist circumference/hip circumference criterion. Results. It was determined that waist circumference is an informative criterion to assess the risk for the development of inflammatory processes in the body, changed metabolism of vaspin, omentin, leptin and free fatty acids; waist circumfe­rence/hip circumference para­meter is informative only to assess the changes of leptin and free fatty acids metabolism. Conclusions. Development of abdominal obesity is accompanied by the risk of local inflammation of fatty tissue, system low intensive inflammation, by the changes of its secretory function in relation to vaspin and omentin, by increase of levels leptin in circulation. Significant correlation was certain between the degree of accumulation of fatty tissue with the changes of vaspin and omentin metabolism.