Theophylline derivatives as potential histamine H3-receptor antagonists.
Copyright policy )Theophylline derivatives as potential histamine H3-receptor antagonists.
Previous results of histamine H3-receptors investigations allowed to formulate a general structure of H3-receptor antagonists. According to this model a series of compounds were obtained. As heterocycles they contained a theophylline moiety connected with a polar group (amine, ester, amide, and thiourea function) via an alkyl chain linked by a spacer to a lipophilic residue. The common distance between xanthine moiety and lipophilic rest was a six-link-chain. Selected compounds did not show significant H3-receptor antagonist activity and were weak antagonists at histamine H1-receptors.
- Jagiellonian University Poland
Theophylline, Ileum, Guinea Pigs, Histamine Antagonists, Animals, Receptors, Histamine H3, Muscle, Smooth, In Vitro Techniques, Muscle Contraction
Theophylline, Ileum, Guinea Pigs, Histamine Antagonists, Animals, Receptors, Histamine H3, Muscle, Smooth, In Vitro Techniques, Muscle Contraction
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).2 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!