[Increasing physical endurance with salmeterol].

10 patients with mild to moderate chronic obstructive pulmonary disease were assessed by lung function tests at rest and spiroergometry before and 1 resp. 7 hours after inhalation of 50 micrograms salmeterol. The parameters changed as follows: Forced exspiratory volume in 1 second: +16% +/- 6% after 1 resp. +13% +/- 5% after 7 hours; airway resistance: -43% +/- 11% resp. -43 +/- 9%. Work capacity at the anaerobic threshold (AT): +44% +/- 17% resp. +37% +/- 16%, oxygen consumption at the AT (VO2AT): +53% +/- 18% resp. +54 +/- 23%, ventilation at the AT (VEAT): +31% +/- 11% resp. 30% +/- 7%. Maximum work capacity: +14 +/- 5% resp. +22 +/- 7%, maximum oxygen consumption (VO2max) +58 +/- 24% resp. 64 +/- 22%, maximum ventilation (VEmax) +33 +/- 10% resp. + 46 +/- 11%. In conclusion, salmeterol leads to a long lasting improvement of exercise capacity. This is related to the improvement of the ventilation caused by salmeterol. Significant changes of heart rate or blood pressure were not observed.

Related Organizations

Universitätsklinikum Aachen
Germany

Keywords

Adult, Male, Anaerobic Threshold, Middle Aged, Bronchodilator Agents, Administration, Inhalation, Exercise Test, Physical Endurance, Humans, Albuterol, Female, Lung Diseases, Obstructive, Lung Volume Measurements, Salmeterol Xinafoate, Aged

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