[Therapeutic approaches targeting HIV reservoirs].
Copyright policy )[Therapeutic approaches targeting HIV reservoirs].
The establishment of latent infection in long-lived cells is the main obstacle to HIV cure or sustained remission without antiretroviral therapy. The most developed therapeutic strategies, in current clinical trials are mainly based on the concept of "shock and kill". They include latency reversing agents (LRAs) to re-activate HIV transcription that can be associated with immunomodulatory treatments. The objective is to eliminate virus-producing cells or to induce the control of HIV after anti-retroviral therapy cessation. HIV reservoir or cancer cells have a number of mechanisms in common. They can escape the immune system and persist by overexpressing survival molecules. This review presents a synthesis of current therapeutic approaches as well as the therapeutic perspectives related to the field of oncology.
- French National Centre for Scientific Research France
- University of Paris France
- Bicêtre Hospital France
- Assistance Publique -Hopitaux De Paris France
- Institut Cochin France
Gene Expression Regulation, Viral, Transcription, Genetic, Anti-HIV Agents, T-Lymphocytes, Toll-Like Receptors, Antibodies, Monoclonal, Apoptosis, HIV Infections, HIV Antibodies, Antibodies, Neutralizing, Immunotherapy, Adoptive, Histone Deacetylase Inhibitors, Chemotaxis, Leukocyte, Histone Methyltransferases, Humans, Virus Activation, Immunotherapy, Disease Reservoirs, Immune Evasion, Transcription Factors
Gene Expression Regulation, Viral, Transcription, Genetic, Anti-HIV Agents, T-Lymphocytes, Toll-Like Receptors, Antibodies, Monoclonal, Apoptosis, HIV Infections, HIV Antibodies, Antibodies, Neutralizing, Immunotherapy, Adoptive, Histone Deacetylase Inhibitors, Chemotaxis, Leukocyte, Histone Methyltransferases, Humans, Virus Activation, Immunotherapy, Disease Reservoirs, Immune Evasion, Transcription Factors
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