ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis.
Copyright policy )ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis.
Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.
Fil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina
Fil: Klepp, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina
Fil: Bigi, Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina
Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía; Argentina
Vaccination, CATTLE, Down-Regulation, MYCOBACTERIUM BOVIS, Aminopeptidases, Mycobacterium bovis, Minor Histocompatibility Antigens, Gene Expression Regulation, 3',5'-Cyclic-AMP Phosphodiesterases, IMMUNE RESPONSE, https://purl.org/becyt/ford/1.6, Host-Pathogen Interactions, Animals, TRANSCRIPTOMICS, Cattle, RNA, Messenger, https://purl.org/becyt/ford/1, Tuberculosis Vaccines, Tuberculosis, Bovine
Vaccination, CATTLE, Down-Regulation, MYCOBACTERIUM BOVIS, Aminopeptidases, Mycobacterium bovis, Minor Histocompatibility Antigens, Gene Expression Regulation, 3',5'-Cyclic-AMP Phosphodiesterases, IMMUNE RESPONSE, https://purl.org/becyt/ford/1.6, Host-Pathogen Interactions, Animals, TRANSCRIPTOMICS, Cattle, RNA, Messenger, https://purl.org/becyt/ford/1, Tuberculosis Vaccines, Tuberculosis, Bovine
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