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UCL Discovery
Article . 2017
Data sources: UCL Discovery
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zbMATH Open
Article . 2017
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A latent class model for competing risks.

A latent class model for competing risks
Authors: Rowley, M.; Garmo, H.; Van Hemelrijck, M.; Wulaningsih, W.; Grundmark, B.; Zethelius, B.; Hammar, N.; +4 Authors

A latent class model for competing risks.

Abstract

Survival data analysis becomes complex when the proportional hazards assumption is violated at population level or when crude hazard rates are no longer estimators of marginal ones. We develop a Bayesian survival analysis method to deal with these situations, on the basis of assuming that the complexities are induced by latent cohort or disease heterogeneity that is not captured by covariates and that proportional hazards hold at the level of individuals. This leads to a description from which risk-specific marginal hazard rates and survival functions are fully accessible, 'decontaminated' of the effects of informative censoring, and which includes Cox, random effects and latent class models as special cases. Simulated data confirm that our approach can map a cohort's substructure and remove heterogeneity-induced informative censoring effects. Application to data from the Uppsala Longitudinal Study of Adult Men cohort leads to plausible alternative explanations for previous counter-intuitive inferences on prostate cancer. The importance of managing cardiovascular disease as a comorbidity in women diagnosed with breast cancer is suggested on application to data from the Swedish Apolipoprotein Mortality Risk Study. Copyright © 2017 John Wiley & Sons, Ltd.

Country
United Kingdom
Keywords

Male, 330, 610, Breast Neoplasms, informative censoring, Risk Assessment, Applications of statistics to biology and medical sciences; meta analysis, survival analysis, Risk Factors, Humans, Longitudinal Studies, competing risks, Proportional Hazards Models, Sweden, Models, Statistical, Prostatic Neoplasms, Bayes Theorem, Competing risks, Survival Analysis, Apolipoproteins, Cardiovascular Diseases, Female, heterogeneity

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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Top 10%
Average
Top 10%
Green
Related to Research communities
Cancer Research