Impact of TIEG1 on the structural properties of fast- and slow-twitch skeletal muscle.
Copyright policy )Impact of TIEG1 on the structural properties of fast- and slow-twitch skeletal muscle.
Transforming growth factor-beta (TGF-β)-inducible early gene-1 (TIEG1) is a transcription factor that is highly expressed in skeletal muscle. The purpose of this study was to characterize the structural properties of both fast-twitch (EDL) and slow-twitch (soleus) muscles in the hindlimb of TIEG1-deficient (TIEG1-/- ) mice.Ten slow and 10 fast muscles were analyzed from TIEG1-/- and wild-type (WT) mice using MRI texture (MRI-TA) and histological analyses.MRI-TA could discriminate between WT slow and fast muscles. Deletion of the TIEG1 gene led to changes in the texture profile within both muscle types. Specifically, muscle isolated from TIEG1-/- mice displayed hypertrophy, hyperplasia, and a modification of fiber area distribution.We demonstrated that TIEG1 plays an important role in the structural properties of skeletal muscle. This study further implicates important roles for TIEG1 in the development of skeletal muscle and suggests that defects in TIEG1 expression and/or function may be associated with muscle disease. Muscle Nerve 55: 410-416, 2017.
- Inserm France
- French National Centre for Scientific Research France
- François Rabelais University France
- Mayo Clinic United States
- SORBONNE UNIVERSITÉ France
structural properties, Male, TIEG1, Principal Component Analysis, Kruppel-Like Transcription Factors, Mice, Transgenic, Magnetic Resonance Imaging, Hindlimb, [SDV] Life Sciences [q-bio], DNA-Binding Proteins, Mice, Inbred C57BL, Mice, Muscle Fibers, Slow-Twitch, Muscle Fibers, Fast-Twitch, Early Growth Response Transcription Factors, magnetic resonance imaging, Animals, Female, Slow and fast muscles, RNA, Messenger, Transcription Factors
structural properties, Male, TIEG1, Principal Component Analysis, Kruppel-Like Transcription Factors, Mice, Transgenic, Magnetic Resonance Imaging, Hindlimb, [SDV] Life Sciences [q-bio], DNA-Binding Proteins, Mice, Inbred C57BL, Mice, Muscle Fibers, Slow-Twitch, Muscle Fibers, Fast-Twitch, Early Growth Response Transcription Factors, magnetic resonance imaging, Animals, Female, Slow and fast muscles, RNA, Messenger, Transcription Factors
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