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[The study of the peculiarities of metabolism in individuals with rs9939609 polymorphism of FTO gene].

Authors: N P, Egorenkova; E Yu, Sorokina; A V, Pogozheva; E V, Peskova; O N, Makurina; L G, Levin; T V, Aristarkhova; +2 Authors

[The study of the peculiarities of metabolism in individuals with rs9939609 polymorphism of FTO gene].

Abstract

A total of 104 people, among them were 18 men and 86 women aged 18 to 67 years--people in the Moscow region of the Russian Federation, in the sanatorium treatment. Association embodiment rs9939609 FTO obesity was studied using allele-specific amplification, detection results in real time using TaqMan-probes complementary DNA polymorphisms. The frequency of the mutant allele in individuals was 47.0%, while the TT genotype was detected in 25.0% of cases, AT--in 56.0%, AA.0%. In men, prevalence rates of obesity risk allele (A) is higher than in women. In individuals with obesity (BMI over 30 kg/m2) indicated the presence of more AA genotypes (2 7.8%) compared to individuals with a body mass index of less than 30 kg/m2 (14.1%) and a high frequency of occurrence (54.2 versus 43.0%) risk allele A. Compared with individuals with genotype TT, the examinees with the AA genotype rs9939609 FTO gene was significantly higher BMI, waist circumference, hip circumference, fat mass. The same patients energy expenditure at rest value, calculated per kg of lean body mass or muscle, was slightly less than with TT genotype. In individuals with the AA genotype rs9939609 FTO gene compared with the TT genotype had significantly lower levels of HDL cholesterol and serum iron in the background significantly elevated concentrations of uric acid. Thus, the evaluation of patients with the use of innovative technologies in a spa treatment allows their personal alimentary correction for the prevention and treatment of non-communicable diseases.

Keywords

Adult, Male, Polymorphism, Genetic, Adolescent, Genotype, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Proteins, Middle Aged, Body Mass Index, Russia, Sex Factors, Mutation, Prevalence, Humans, Female, Obesity, Waist Circumference, Alleles, Aged

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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