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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao zbMATH Openarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Article . 2016
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Receiver operating characteristic analysis under tree orderings of disease classes.

Receiver operating characteristic analysis under tree orderings of disease classes
Authors: Wang, Dan; Attwood, Kristopher; Tian, Lili;

Receiver operating characteristic analysis under tree orderings of disease classes.

Abstract

Receiver operating characteristic (ROC) curve and its summary statistics (e.g., the area under curve (AUC)) are commonly used to evaluate the diagnostic accuracy for disease processes with binary classification. The ROC curve has been extended to ROC surface for scenarios with three ordinal classes or to hyper-surface for scenarios with more than three classes. For classifier under tree or umbrella ordering in which the marker measurement for one class is lower or higher than those for the other classes, the commonly adopted diagnostic measures are the naive AUC (NAUC) based on a pooled class of all the unordered classes and the umbrella volume (UV) based on the concept of volume under surface. However, both NAUC and UV have some limitations. For example, NAUC depends on the sampling weights for all the classes in population, and UV has only been introduced for three-class settings. In this article, we initiate the idea of a new ROC framework for tree or umbrella ordering (denoted as TROC) and propose the area under TROC curve (denoted as TAUC) as an appropriate diagnostic measure. The proposed TROC and TAUC share many nice features with the traditional ROC and AUC. Both parametric and nonparametric approaches are explored to construct the confidence interval estimation of TAUC. The performances of these methods are compared in simulation studies under a variety settings. At the end, the proposed methods are applied to a published microarray data set.

Related Organizations
Keywords

AUC for tree ordering (\textit{TAUC}), Lung Neoplasms, receiver operating characteristic (ROC) curve, Applications of statistics to biology and medical sciences; meta analysis, naive AUC (\textit{NAUC}), Gene Expression Regulation, Neoplastic, ROC Curve, Area Under Curve, Biomarkers, Tumor, (ROC) for tree ordering (\textit{TROC}), Humans, Computer Simulation, area under curve (AUC)

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
11
Top 10%
Average
Average
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