While there is reinforcement of the idea that loss of body mass (BM) will lead to an improvement in overall health status for the individual that is overfat, or obese. The long held recommendation for reduction of BM focusing solely on establishing a reduction on caloric intake, via caloric restriction (CR) in diet alone tends to limited impact on overall health status changes for these individuals. In contrast, the reduction of BM attained through employment of therapeutic exercises produces a significant change in the health status of individuals that are overfat, or obese. While endurance training (ET) is readily recommended, it may be far less effective at correcting these underlying issues relative to changes noted in response resistance training (RT) programs. Therefore this review will examine the differential responses seen with the application of RT related to the positive adaptations in BM modifications, regardless of changes in Body Mass Index (BMI), and proper hormonal responses leads to modifications of health status and eventually returning the individual who is overfat, or obese, back to a normal health status with the employment of RT in a therapeutic exercise program.