Inflammation: IL-36 has proinflammatory effects in skin but not in joints.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2014 Switzerland English Journal:Nature reviews. Rheumatology, volume 10 (issn: 1759-4804,

Copyright policy )Funded by:SNSF | The biological function o...

Authors: Dietrich Damien; Gabay Cem;

pmid: 25201385

Inflammation: IL-36 has proinflammatory effects in skin but not in joints.

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Abstract

Given the known involvement of IL-36 in psoriasis it might be surprising that the latest mouse models show that inhibiting IL-36 signalling does not alter the course of inflammatory arthritis. Can we now add IL-36 to the list of inflammatory mediators that are not viable DMARD targets?

Country

Switzerland

Related Organizations

University of Geneva
Switzerland
University Hospital of Geneva
Switzerland

Keywords

Inflammation, Synovitis, Arthritis, Synovial Membrane, Receptors, Interleukin-1, Dermatitis, Receptors, Interleukin, 616.07, Arthritis, Experimental, Mice, 616, Animals, Humans, Psoriasis, Interleukin-1, Skin

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